Global Enzymatic DNA Synthesis Market

Enzymatic DNA Synthesis Market Summary

The Global Enzymatic DNA Synthesis Market Size Was Estimated at USD 267.4 Million in 2024, is Projected to Reach USD 3672.5 Million by 2035, Expanding at a CAGR of 26.89% from 2025 to 2035. The market for enzymatic DNA synthesis is expanding as a result of growing applications in diagnostics and pharmaceuticals, growing genomic research, advances in synthetic biology, and the need for quicker, more precise DNA synthesis.

Key Regional and Segment-Wise Insights

• In 2024, the North American market for enzymatic DNA synthesis accounted for 48.42% and led the global market.
• The oligonucleotide synthesis segment had the largest market share by services in 2024.
• In 2024, the synthetic biology segment had the largest market share, accounting for 35.72% based on application.

Global Market Forecast and Revenue Outlook

• 2024 Market Size: USD 267.4 Million
• 2035 Projected Market Size: USD 3672.5 Million
• CAGR (2025-2035): 26.89%
• North America: Largest market in 2024
• Asia Pacific: Fastest growing market

The enzymatic DNA synthesis market functions by creating DNA strands through enzymatic processes rather than the traditional chemical methods. A new DNA synthesis approach employs enzymes to link nucleotides, thus producing faster, precise, and environmentally friendly DNA synthesis. The increasing demand for synthetic DNA across biomedical research and development and genomic and personalized medicine applications drives this industry forward. Research and treatment development require efficient DNA synthesis methods because infectious diseases and genetic conditions continue to escalate in prevalence. The increasing worldwide investments in the biotechnology and pharmaceutical sectors drive market growth through their support of advanced genetic analysis and editing technologies.

The enzymatic DNA synthesis market experiences substantial changes from technological progress that focuses on enhancing both strand length and synthesis speed and precision. The method benefits from advancements such as template-independent enzymatic synthesis and automated platform integration, which enhance its scalability and operational efficiency. Market growth receives additional momentum through government funding programs for both North American and European and Asian-Pacific precision medicine and synthetic biology research. The market environment for enzymatic DNA synthesis technologies benefits from increased support that comes from joint activities between academic organizations, industrial entities, and regulatory bodies.

Services Insights

The oligonucleotide synthesis segment dominated the enzymatic DNA synthesis market, accounting for the largest revenue share in 2024.  The extensive adoption of enzymatic synthesis techniques for producing short DNA strands known as oligonucleotides drives this segment's market leadership because these molecules serve vital functions in gene editing, as well as PCR primers and diagnostic tools, and therapeutic applications. The requirement for exact high-quality oligonucleotides generated quickly in both clinical and research environments propels this market forward. The faster synthesis times and decreased environmental impact from enzymatic methods compared to chemical synthesis lead to increased adoption of these methods. The oligonucleotide synthesis segment will maintain its market leadership in enzymatic DNA synthesis because genetic research, together with personalized medicine, continues to expand.

During the projected period, the gene synthesis segment of the enzymatic DNA synthesis market is anticipated to grow at the fastest CAGR. Synthetic biology and genetic engineering, together with medicinal research, require extended and intricate DNA sequences, which drives this rapid market growth. The pharmaceutical companies and researchers select enzymatic DNA synthesis because it offers superior accuracy, together with efficient gene synthesis compared to traditional chemical methods. Large-scale production of high-quality gene constructs now exists due to advancements in enzyme technology, together with automated systems. The growing importance of gene therapy alongside personalized medicine and vaccine development drives the demand for effective gene synthesis methods. The enzymatic DNA synthesis market sector demonstrates strong growth potential, which will drive the overall market expansion.

Application Insights

The synthetic biology segment led the enzymatic DNA synthesis market with the largest revenue share of   35.72% in 2024. Enzymatic DNA synthesis maintains its market leadership because researchers use it to develop custom genetic sequences for biological system construction. The majority of new species creation, along with biofuel production, pharmaceutical development, and biomaterial manufacturing, depends heavily on precise and effective DNA synthesis through synthetic biology. The rising use of enzymatic DNA synthesis across healthcare, agricultural, and environmental sectors and increased funding in synthetic biology research drive up market demand. Synthetic biology projects benefit from enzymatic synthesis because of its accurate results and short processing times. Enzymatic DNA synthesis will remain the market leader in this sector because synthetic biology continues its development.

The vaccine development segment of the Enzymatic DNA synthesis market is anticipated to grow at a significant CAGR over the forecast period. The rising demand for fast and accurate DNA manufacturing techniques, which serve essential roles in vaccine production and manufacturing, especially for emerging infectious diseases, drives this expanding market. The benefits of enzymatic DNA synthesis include precise operations alongside fast processing speed, and reduced mistakes compared to traditional chemical synthesis methods. These benefits make it the perfect choice for developing mRNA vaccines and various gene-based therapeutic approaches. Enzymatic DNA synthesis applications in vaccine R&D continue to accelerate because of ongoing progress in synthetic biology, together with personalized medicine.

Regional Insights

North America dominated the enzymatic DNA synthesis market with the largest revenue share of 48.42% in 2024. The region leads because it hosts numerous biotechnology and pharmaceutical companies, which support advanced genetic research and synthetic biology. The market growth receives strong support from extensive funding in genomics and precision medicine, along with advanced research facilities and large-scale adoption of modern technologies. The increasing demand for DNA synthesis in gene therapy and vaccine development, and diagnostic fields, strengthens North America's leading market position. The market leader status of this region will remain stable throughout the forecast period because of its major companies and ongoing enzymatic synthesis technology development that drives global DNA synthesis advancements.

Europe Enzymatic DNA Synthesis Market Trends

The European market for enzymatic DNA synthesis is expected to grow significantly because of increased biotechnology research spending and growing synthetic biology applications. The European countries direct their efforts towards vaccine development and gene therapy, along with personalized medicine, which needs precise DNA synthesis techniques. Government funding, together with life sciences and genomics research support programs, drives market growth. The startup ecosystem, in combination with established businesses in this region, advances technological progress in enzymatic DNA synthesis. The strong European regulatory system, together with academic-industrial partnerships, enables the development and market release of innovative DNA synthesis methods.

Asia Pacific Enzymatic DNA Synthesis Market Trends

The enzymatic DNA synthesis market in the Asia Pacific will experience the fastest growth during the forecast period because of rising genomic research expenses and biotechnology advancements in the region. The market continues to grow because developing countries such as China, India, and Japan need efficient, cost-effective DNA synthesis methods. The area benefits from a large number of skilled researchers, together with its progressively expanding life sciences research infrastructure. The development of enzymatic DNA synthesis technology, together with its adoption, receives support from increasing government investment as well as favorable regulatory environments and academic-industrial collaboration. The expanding applications in synthetic biology, together with customized medical approaches and vaccine production, stand as crucial factors for market growth in the Asia Pacific region.

Key Enzymatic DNA Synthesis Companies:

The following are the leading companies in the enzymatic DNA synthesis market. These companies collectively hold the largest market share and dictate industry trends.

• Telesis Bio Inc.
• Touchlight
• Camena Bio
• Twist Bioscience Corporation
• Evonetix
• Molecular Assemblies
• Ansa Biotechnologies, Inc.
• GenScript Biotech Corp.
• Kern Systems
• DNA Script
• Others

Recent Developments

• In May 2025, the Gibson SOLA enzymatic synthesis technology, which Telesis Bio has licensed to Regeneron, allows for high-throughput, on-demand gene synthesis right in Regeneron's research and development facilities.  This calculated action highlights the increasing usage of enzymatic DNA synthesis for flexible, in-house workflows and promotes quicker biologics discovery by cutting the time needed to produce DNA and mRNA from weeks to hours.
• In February 2025, to expedite the creation of mRNA vaccines, researchers in Paris are using enzymatic DNA synthesis technology.  DNA Script, which received USD 4.7 million in CEPI funding, intends to automate the production of synthetic DNA templates in order to expedite vaccine timeframes and increase accessibility worldwide, particularly in the Global South.

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the enzymatic DNA synthesis market based on the below-mentioned segments:  

Global Enzymatic DNA Synthesis Market, By Services

• Oligonucleotide Synthesis
• Gene Synthesis

Global Enzymatic DNA Synthesis Market, By Application

• Synthetic Biology
• Genetic Engineering
• Vaccine Development
• Others

Global Enzymatic DNA Synthesis Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa